UHN scientists discover potential treatment for glaucoma

A Toronto-based research team has identified a new neuroprotective factor that has the potential to help people suffering from the common blinding disease glaucoma.

The team led by scientists at the Krembil Research Institute studied the different functions of cells in the retina and optic nerve. The team identified an unconventional signal – a unique lipid called LXB4 that protects these neurons against the harmful effects of glaucoma in preclinical models.

“This discovery provides hope that we can devise a new strategy for protecting the vision of glaucoma patients,” said principal investigator Dr. Jeremy Sivak, who holds the glaucoma research chair at the Donald K. Johnson Eye Institute at the University Health Network (UHN )and is associate professor at the University of Toronto School of Medicine.

The research team, which was led by Dr. Sivak and assisted by Dr. John Flanagan and Dr. Karsten Gronert of the University of California, Berkeley, published its findings today in a featured article in the Journal of Clinical Investigation.

“We found that this tiny lipid molecule is normally present in healthy eyes and acts as a neuroprotective signal,” said Sivak. “Healthy eyes produce LXB4, but in diseased eyes, its levels are reduced. We showed that by restoring LXB4 we can preserve injured nerve cells from dysfunction and death.”

Glaucoma is a progressive neurodegenerative disease of the optic nerve that is irreversible and can eventually lead to blindness. It affects more than 400,000 Canadians and 70 million people worldwide.

There is no known cure, and current treatments are limited to reducing eye pressure (a risk factor often associated with the disease). A method to preserve the survival of nerve cells is a major research and pharmaceutical goal for all neurodegenerative conditions.

“A particularly exciting part of this discovery is that we don’t think this effect is limited to glaucoma,” said Sivak. “This neuroprotection extends to the central nervous system and could be applicable to a host of other neurodegenerative diseases.”

The team now plans to conduct further investigation of the mechanisms that underpin this signal in the eye and designing a practical method to activate it in the clinic. Researchers also plan to explore the potential application of this discovery to various other conditions, such as Alzheimer’s disease and Parkinson’s disease.

Funding for this study was provided by the Canadian Institutes for Health Research, The Natural Sciences and Engineering Research Council of Canada, the National Institutes of Health and the Toronto General and Western Hospital Foundation.

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