The Thermo Scientific Orbitrap Fusion Lumos Tribrid Mass Spectrometer is the most advanced mass spectrometry system that can be upgraded to even higher resolution, additional dissociation capabilities (UVPD and ETD), and a unique internal calibration (IC).
Achieve clear characterization of lipids, modified peptides and intact proteins, even in complex mixtures, and obtain unique structurally diagnostic information . UV photodissociation enhances unique sequence coverage over 20%, generating MSn fragments in the linear ion trap that can be detected by either the ion trap or Orbitrap mass analyzer.
Resolve isobaric components, obtain fine isotope information, and achieve confident assignment of the elemental composition of small molecule analytes with the ultra-high resolution setting. The high resolution option significantly aids the characterization and quantitation of structurally diverse targets.
Experience enhanced resolution of peptides and proteins with Easy-ETD, which introduces electron transfer dissociation using Townsend discharge ionization to create a highly stable reagent ion flux and is compact enough to fit behind the ion funnel. ETD and EThcD high collision disocciation modes are available and increase detection limits and dynamic range of ETD spectra.
Improve mass-to-charge (m/z) ratio assignment accuracy to under 1 ppm with Easy-IC, which incorporates a second ion source that delivers a regulated number of calibrant ions into the analyte ions. This feature enables real-time fine adjustment of the instrument’s m/z calibration, correcting otherwise uncompensated errors due to temperature fluctuations and scan-to-scan variations.